The Biochemical Basis of NeuropharmacologyThis classic text gives a uniquely lucid and lively view of neurotransmitters, their role in nervous system function, and their involvement in the mechanisms of psychiatric drug action. For three decades it has served as an essential guide for students of neuroscience and psychopharmacology, residents in psychiatry and neurology, and clinicians and scientists. Both authoriative and very readable, it has been thoroughly updated for each edition. In the 8th Edition more space is devoted to clinical examples, subclasses of receptors that provide targets for new drugs, molecular genetics, the major problem of drug delivery to the brain, and the growing recognition of nicotin receptors in the brain and their possible involvement in Alxheimer's and Parkinson's diseases. In addition, the book's format has been enlarged and a second color added to many of the illustrations. |
Contents
Introduction | 1 |
Cellular Foundations of Neuropharmacology | 7 |
Molecular Foundations of Neuropharmacology | 39 |
Receptors | 65 |
Modulation of Synaptic Transmission | 85 |
Amino Acid Transmitters | 105 |
Acetylcholine | 149 |
Norepinephrine and Epinephrine | 179 |
Dopamine | 223 |
Serotonin 5Hydroxytryptamine Histamine and Adenosine | 269 |
Neuroactive Peptides | 319 |
355 | |
371 | |
399 | |
Other editions - View all
The Biochemical Basis of Neuropharmacology Jack R. Cooper,Floyd E. Bloom,Robert H. Roth Limited preview - 2003 |
The Biochemical Basis of Neuropharmacology Jack R. Cooper,Floyd E. Bloom,Robert H. Roth No preview available - 2003 |
Common terms and phrases
5-HT receptors acetylcholine action activity adenosine adenylyl cyclase affinity agents agonists amino acid antagonists antipsychotic antipsychotic drugs autoreceptors axon behavioral binding biochemical block brain Ca2+ catecholamine cells cellular central ceptor choline cholinergic cloned concentration cortex cortical D₁ D2 receptors decarboxylase depolarization disease DOPA dopamine neurons dopamine receptors dopaminergic effects endogenous enzyme excitatory function GABA GABAA receptor gene glutamate histamine hormone hydroxylase increase inhibition inhibitors interaction intracellular ion channels levels ligand locus ceruleus mammalian mechanisms mediated membrane metabolism MHPG modulation molecular molecules monoamine mRNA nerve terminal nervous system neurons neuropeptides neurotensin neurotransmitter NMDA receptor noradrenergic norepinephrine nucleus opioid pathway peptide peripheral pharmacological phosphorylation physiological plasma postsynaptic potential presynaptic protein kinase recep receptor subtypes regulation release response reuptake role selective sequence serotonin specific stimulation structure studies substrate subunits synaptic synthesis tion tissue transmission transmitter transporter tryptophan tyrosine uptake vasopressin vesicles
Popular passages
Page 354 - Overproduction of corticotropin-releasing factor in transgenic mice: A genetic model of anxiogenic behavior. J Neurosci 14: 2579-2584, 1994.