Levodopa failure in chronic manganism

Neurology. 1994 Sep;44(9):1600-2. doi: 10.1212/wnl.44.9.1600.

Abstract

We report a placebo-controlled study of levodopa in four patients with extrapyramidal deficits caused by chronic manganese intoxication. Their parkinsonism and dystonia had progressed slowly over a period of 5 years after they left the site of exposure. Initially the patients appeared to respond to levodopa in open observations, but this apparent benefit was not sustained. This short-term, double-blind study indicates that their parkinsonism and dystonia failed to respond to levodopa.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronic Disease
  • Double-Blind Method
  • Humans
  • Levodopa / therapeutic use*
  • Male
  • Manganese Poisoning*
  • Middle Aged
  • Movement Disorders / drug therapy*
  • Movement Disorders / etiology*
  • Nervous System Diseases / chemically induced*
  • Nervous System Diseases / drug therapy*
  • Placebos

Substances

  • Placebos
  • Levodopa