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1. Drug-resistant bacteria ranked 2017

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwGP3QDcEXL1PwMkcfFPQhbl2ytoMxWatzKuLQKeKLNGmiL865y__3-9IWp4IvvpzQlEKb60ny9RyAfdLMkqJmGFfGMJGoJpMm0KwZS6TzdW4Sob9v5qTRhPQvTFa_-bBox-rkXdE2eZXs43A6b3jiZPTByDiKDlgzF41FKLpIJci9IYjmojx-CDHnB5s8qKbKmRTd5R_Xian_Go7tHNNdhbf87WxoCRkazMfYV62uoRWzyDUc__Ula7CSkVGnk7aedVjQwxIs2aBQNSnBetbxJ85hpk59tAEHp-PZC8NFOhHP4dRpvbZlqvgct6qvbYdM4HWyCffds0HUY5nXAhu5Lp8y5B2K88QPZOAngVASpzbXIB1RMTlxIC_UyuO6FpuGwTWtbPJaU-No0ZBIMTxP8i1wpOGuMImH-UbEvoy14CZWXHhCG1lT21DOS-M56ymT56-i2Pn79i4sU1XZ-K96GQrT8UzvQYFqoQKL_u0D4eCc8NG3GFZsW6hAsRNeRl1KB1H_DnPDswivwqu7zi2mveii-4S5V-Ex4nX92uKNxT6hnyI92W88fQJy98iK

   Willyard, Cassandra

   Nature (London), Vol. 543, Issue 7643, p. 15.

   The World Health Organization (WHO) has for the first time released a list of the drug-resistant bacteria that pose the greatest threat to human health and for which new antibiotics are desperately... Read more

   The World Health Organization (WHO) has for the first time released a list of the drug-resistant bacteria that pose the greatest threat to human health and for which new antibiotics are desperately needed. Read less

   Journal Article  |  Full Text Online

2. ‘Phase transitions’ in bacteria – From structural transitions in free living bacteria to... 2022

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LSwMxEA7SInjxjdYXETy6uJtku12QgohFEcSDXryEzW6GVrQtbT1463_won_AH9Zf4sxmV3xUEY-7ZPaRmWS-JB_fMLZHmllG-eDJFMBTWRp7BhrWixODcF5IyJT9vJnjForDKUf4ORWrT9KcuJYTItckJfnPKmWeRoVVj87OTy_KuRfRQV4rLQgj4vOosNQZmv6Yn3LRVKwpipzTWmA35dfmVBMqcPCRc3-Q6xzm4halpuPf_2yRzRdIlB-50FliM7a7zGZdbcrHFfY6GT9ftjHH8RGlM8fsmoxfeKfLD9tN41Sek8ODdpNPxk-8Nejdc6dGS0oeH63IBAbW8rsObV98Mx_1ODHNeqPHfif9avi1MW0c423ToVrj98NVdt06uTo-9YqiDl4qw3jkqURmkSAKlgJc_2FgCBMYmZlYJNbUAZQBCYEPCFSM8cMGghBEWRFYX9jQNuQ649giUJDVbeSDSiKTWCUhSaWqKwvGT2tsv_Sr7jvRDl2y2W513uea-lz7scY-r7F66Xtd4A6HJzQ67HfD3TJSNI5KOmpJurb3MNQiQigZBjh519iaC6H3L0HIEJKw3MZ_X7vJ5ujKkWq2WAVda7dZheJvpxgQb5piESw

   Wang, Xiaoling; Blumenfeld, Raphael; Feng, Xi-Qiao; Weitz, David A.

   Physics Of Life Reviews, Vol. 43, pp. 98 - 138.

   •Experimental and theoretical efforts toward understanding phase transitions in bacteria are summarised and reviewed.•We analyse in detail transitions in: flagellar rotation mode, biofilm structure... Read more

   •Experimental and theoretical efforts toward understanding phase transitions in bacteria are summarised and reviewed.•We analyse in detail transitions in: flagellar rotation mode, biofilm structures, and phenotypical changes.•Correlation between conventional phase transitions and the transitions in bacteria are highlighted and summarised.•We summarise applications of theoretical and numerical methods, originally developed in physics, for modelling transitions in bacteria. Phase transitions are common in inanimate systems and have been studied extensively in natural sciences. Less explored are the rich transitions that take place at the micro- and nano-scales in biological systems. In conventional phase transitions, large-scale properties of the media change discontinuously in response to continuous changes in external conditions. Such changes play a significant role in the dynamic behaviours of organisms. In this review, we focus on some transitions in both free-living and biofilms of bacteria. Particular attention is paid to the transitions in the flagellar motors and filaments of free-living bacteria, in cellular gene expression during the biofilm growth, in the biofilm morphology transitions during biofilm expansion, and in the cell motion pattern transitions during the biofilm formation. We analyse the dynamic characteristics and biophysical mechanisms of these phase transition phenomena and point out the parallels between these transitions and conventional phase transitions. We also discuss the applications of some theoretical and numerical methods, established for conventional phase transitions in inanimate systems, in bacterial biofilms. Read less

   Journal Article  |  Full Text Online

3. Bacteria-cancer interactions: bacteria-based cancer therapy 2019

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa9RAEF5sBfFFtBWN1hBEfBC22WQ3l6yUQu_w6D0U-qAgviz7s3fUS0uuPvS_d2aTFCM--ZLAZjcsM7PMN7sz3xLyATmzjGCBchsCFc5KakLjqdQG4HzJgxN-uplDqrEWJibtW7M5bn9uj9vNOuZW3m5tPuaJ5ZcXCyTX5azM98hezcUYog9RViUi9XIBuIJycFbjUSZv8h001hhAS4p3NlG8Bg5suqzZTEz8UqTvB2_TduFfyPPvBMqeXip6pOVz8myAktlZP-UX5JFvD8jhWQth9PY--5jF5M64a35AnlwMZ-iHZHWyPp33HM36JF-fUouK7zIkjuj6Mofd5ww6mT87obdz2dC1L9q6f0m-Lb98XZzT4UIFaivJ7yiW3RrAe156aRle98k18432ri6cg0hEgvcuHC-CtUGzqrSAjzQ4LOuC5rzkr0lmAi9EcDNfsyB0bbQXPGjLxUz4YJhNyKdRjuq2J8xQ8aCbN6qXvwL5K5S_YgmZo6QfOiLXdWy46a7UoHEFIZ2sAnMADa2wtdXBysa6Uhqvq5krEvIe9KSu7SaOx_fVjbruFEQEK4WIrOJVQo5GNaphle4UokmJHITwj1e9Rh-mMtpFQuqJridznX4Bc4383IN5vvnvkW_J0xKNtChpURyR_bvul39H9rGoIwWT_17H5zyNGwgpeXy-WC1_pJi2epnGxfAbFP8G7g

   Duong, Mai Thi-Quynh; Qin, Yeshan; You, Sung-Hwan; Min, Jung-Joon

   Experimental & Molecular Medicine, Vol. 51, Issue 12, pp. 1 - 15.

   Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy, have raised the hope for cures for many cancer types. However, there are still ongoing challenges to the pursuit ... Read more

   Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy, have raised the hope for cures for many cancer types. However, there are still ongoing challenges to the pursuit of novel therapeutic approaches, including high toxicity to normal tissue and cells, difficulties in treating deep tumor tissue, and the possibility of drug resistance in tumor cells. The use of live tumor-targeting bacteria provides a unique therapeutic option that meets these challenges. Compared with most other therapeutics, tumor-targeting bacteria have versatile capabilities for suppressing cancer. Bacteria preferentially accumulate and proliferate within tumors, where they can initiate antitumor immune responses. Bacteria can be further programmed via simple genetic manipulation or sophisticated synthetic bioengineering to produce and deliver anticancer agents based on clinical needs. Therapeutic approaches using live tumor-targeting bacteria can be applied either as a monotherapy or in combination with other anticancer therapies to achieve better clinical outcomes. In this review, we introduce and summarize the potential benefits and challenges of this anticancer approach. We further discuss how live bacteria interact with tumor microenvironments to induce tumor regression. We also provide examples of different methods for engineering bacteria to improve efficacy and safety. Finally, we introduce past and ongoing clinical trials involving tumor-targeting bacteria. Read less

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