Medical and drug risk factors associated with neuroblastoma: a case-control study

J Natl Cancer Inst. 1987 May;78(5):797-804.

Abstract

A matched case-control study of prenatal risk factors for neuroblastoma was conducted, including 104 cases diagnosed over the period 1970-79 in the Greater Delaware Valley. Significantly elevated odds ratios (ORs) were associated with maternal use of a neurally active drug during pregnancy (OR = 2.83), sex hormone exposure 3 months prior to or during pregnancy (OR = 2.25), frequent alcohol consumption during pregnancy (OR = 9.0), and maternal use of diuretic drugs during pregnancy (OR = 5.75). Significantly more case mothers than control mothers reported use of hair coloring products during pregnancy (OR = 3.0). No association was found between cigarette smoking, coffee consumption, or medical irradiation and case-control status.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Drinking
  • Antiemetics / adverse effects
  • Coffee / adverse effects
  • Diuretics / adverse effects
  • Female
  • Fetus / drug effects*
  • Fetus / radiation effects
  • Gonadal Steroid Hormones / adverse effects
  • Hair Dyes / adverse effects
  • Humans
  • Infant
  • Neuroblastoma / etiology*
  • Neuroblastoma / genetics
  • Phenobarbital / adverse effects
  • Pregnancy
  • Risk
  • Smoking

Substances

  • Antiemetics
  • Coffee
  • Diuretics
  • Gonadal Steroid Hormones
  • Hair Dyes
  • Phenobarbital