[Coagulopathy and differentiation syndrome: the main complications of the initial treatment of acute promyelocytic leukemia]

Vnitr Lek. 2008 Jul-Aug;54(7-8):745-50.
[Article in Czech]

Abstract

Two main causes of early mortality of acute promyelocytic leukemia (APL) are rewieved, unique type ofcoagulopathy typical for APL and differentiation syndrome sometimes complicating treatment of APL with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO). The information covers analysis of the patophysiologies of both conditions and also recommendations considering treatments and preventive measures.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Arsenic Trioxide
  • Arsenicals / adverse effects*
  • Arsenicals / therapeutic use
  • Disseminated Intravascular Coagulation / etiology*
  • Hemorrhage / etiology
  • Humans
  • Leukemia, Promyelocytic, Acute / complications
  • Leukemia, Promyelocytic, Acute / drug therapy*
  • Leukocytosis / chemically induced*
  • Oxides / adverse effects*
  • Oxides / therapeutic use
  • Respiratory Insufficiency / chemically induced*
  • Syndrome
  • Thrombocytopenia / etiology
  • Tretinoin / adverse effects*
  • Tretinoin / therapeutic use

Substances

  • Antineoplastic Agents
  • Arsenicals
  • Oxides
  • Tretinoin
  • Arsenic Trioxide