Dendritic-cell interactions with HIV: infection and viral dissemination

Nat Rev Immunol. 2006 Nov;6(11):859-68. doi: 10.1038/nri1960.

Abstract

Dendritic cells (DCs) are crucial for the generation and the regulation of adaptive immunity. Because DCs have a pivotal role in marshalling immune responses, HIV has evolved ways to exploit DCs, thereby facilitating viral dissemination and allowing evasion of antiviral immunity. Defining the mechanisms that underlie cell-cell transmission of HIV and understanding the role of DCs in this process should help us in the fight against HIV infection. This Review highlights the latest advances in our understanding of the interactions between DCs and HIV, focusing on the mechanisms of DC-mediated viral dissemination.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology
  • Cell Adhesion Molecules / immunology
  • Dendritic Cells / immunology*
  • HIV / immunology*
  • HIV Infections / immunology*
  • HIV Infections / transmission*
  • HIV Infections / virology
  • Humans
  • Lectins, C-Type / immunology
  • Receptors, Cell Surface / immunology
  • Virus Internalization

Substances

  • Cell Adhesion Molecules
  • DC-specific ICAM-3 grabbing nonintegrin
  • Lectins, C-Type
  • Receptors, Cell Surface