Role of Toll-like receptors in inflammatory response in macrophages

Crit Care Med. 2001 Jul;29(7 Suppl):S16-8. doi: 10.1097/00003246-200107001-00008.

Abstract

The innate immune response is the first line of defense against infectious disease. It is vital that the host detect the pathogen and rapidly mount a defense. The Toll-like family of receptors have evolved to detect conserved patterns on pathogens. When stimulated, these receptors activate the inflammatory response.

Publication types

  • Review

MeSH terms

  • Bacterial Infections / immunology*
  • Drosophila Proteins*
  • Humans
  • Immunity, Innate / immunology*
  • Inflammation / immunology
  • Lipopolysaccharides / immunology
  • Macrophage Activation / immunology*
  • Macrophages / immunology*
  • Membrane Glycoproteins / immunology*
  • Receptors, Cell Surface / immunology*
  • Signal Transduction / immunology
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors